Ruxolitinib reverses Dysregulated T Helper Cell Responses and controls Autoimmunity caused by a Novel STAT1 Gain of Function Mutation

BACKGROUND: Gain of function (GOF) mutations in the human Signal Transducer and Activator of Transcription 1 (STAT1) manifest in immunodeficiency and autoimmunity with impaired T helper (T(H)) 17 cell differentiation and exaggerated responsiveness to types I and II interferon. Allogeneic bone marrow...

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Publicado no:J Allergy Clin Immunol
Main Authors: Weinacht, Katja G., Charbonnier, Louis-Marie, Alroqi, Fayhan, Plant, Ashley, Qiao, Qi, Wu, Hao, Ma, Clement, Torgerson, Troy R., Rosenzweig, Sergio D., Fleisher, Thomas A., Notarangelo, Luigi D., Hanson, Imelda C., Forbes, Lisa R., Chatila, Talal A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482293/
https://ncbi.nlm.nih.gov/pubmed/28139313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.11.022
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