HSVtk/GCV system on hepatoma carcinoma cells: Construction of the plasmid pcDNA3.1-pAFP-TK and targeted killing effect

Previous studies demonstrated that herpes simplex virus thymidine kinase (HSVtk) could phosphorylate non-toxic gancyclovir (GCV) efficiently to produce phosphorylated products that result in cell apoptosis, to kill tumor cells. The present study aimed to construct a plasmid vector, pcDNA3.1-pAFP-TK,...

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Publicat a:Mol Med Rep
Autors principals: Li, Yong-Fang, Yuan, Yang-Yang, Zhang, Ying-Min, Zhao, Na, Zhang, Qi, Meng, Fan-Xiu, Gao, Ran-Peng, Yu, Bao-Feng, Zhang, Yue-Hong, Guo, Rui, Wang, Hai-Long, Xie, Jun, Xu, Jun, Qin, Qin, Dong, Xiu-Shan
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2017
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482189/
https://ncbi.nlm.nih.gov/pubmed/28560395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2017.6657
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