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Enhanced effect of nuclear localization signal peptide during ultrasound-targeted microbubble destruction-mediated gene transfection

Ultrasound-targeted microbubble destruction (UTMD) can promote the entry of plasmid DNA (pDNA) into the cell cytoplasm, by increasing the permeability of the cell membrane. But the transfection efficiency remains low due to inability of the pDNA to enter the nucleus. Various methods have been explor...

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Detalhes bibliográficos
Publicado no:Mol Med Rep
Main Authors: Cao, Sheng, Zhou, Qing, Chen, Jin-Ling, Jiang, Nan, Wang, Yi-Jia, Deng, Qing, Hu, Bo, Guo, Rui-Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482142/
https://ncbi.nlm.nih.gov/pubmed/28586046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2017.6661
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