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Evidence for susceptibility of intrathymic T-cell precursors and their progeny carrying T-cell antigen receptor phenotypes TCR alpha beta + and TCR gamma delta + to human immunodeficiency virus infection: a mechanism for CD4+ (T4) lymphocyte depletion.

Individuals infected by the human immunodeficiency virus type 1 (HIV-1) demonstrate progressive depletion and qualitative dysfunction of the helper T4 (CD4+) cell population. Mechanisms proposed for attrition of CD4+ T cells include direct cytopathicity of these mature cells following infection as w...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Schnittman, S M, Denning, S M, Greenhouse, J J, Justement, J S, Baseler, M, Kurtzberg, J, Haynes, B F, Fauci, A S
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1990
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54821/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2217206/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.19.7727
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