Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism Are Associated With Protein Ingestion–Induced Insulin Resistance

Systemic hyperaminoacidemia, induced by either intravenous amino acid infusion or protein ingestion, reduces insulin-stimulated glucose disposal. Studies of mice suggest that the valine metabolite 3-hydroxyisobutyrate (3-HIB), fibroblast growth factor 21 (FGF21), adiponectin, and nonesterified fatty...

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Foilsithe in:Diabetes
Main Authors: Harris, Lydia-Ann L.S., Smith, Gordon I., Patterson, Bruce W., Ramaswamy, Raja S., Okunade, Adewole L., Kelly, Shannon C., Porter, Lane C., Klein, Samuel, Yoshino, Jun, Mittendorfer, Bettina
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Diabetes Association 2017
Ábhair:
Obesity Studies
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482083/
https://ncbi.nlm.nih.gov/pubmed/28473464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1475
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