Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance

The pH-dependent partitioning of chemotherapeutic drugs is a fundamental yet understudied drug distribution mechanism that may underlie the low success rates of current approaches to counter multidrug resistance (MDR). This mechanism is influenced by the hypoxic tumour microenvironment and results i...

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Udgivet i:Nat Commun
Main Authors: Lucien, Fabrice, Pelletier, Pierre-Paul, Lavoie, Roxane R., Lacroix, Jean-Michel, Roy, Sébastien, Parent, Jean-Luc, Arsenault, Dominique, Harper, Kelly, Dubois, Claire M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482059/
https://ncbi.nlm.nih.gov/pubmed/28635961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15884
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