Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance

The pH-dependent partitioning of chemotherapeutic drugs is a fundamental yet understudied drug distribution mechanism that may underlie the low success rates of current approaches to counter multidrug resistance (MDR). This mechanism is influenced by the hypoxic tumour microenvironment and results i...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Lucien, Fabrice, Pelletier, Pierre-Paul, Lavoie, Roxane R., Lacroix, Jean-Michel, Roy, Sébastien, Parent, Jean-Luc, Arsenault, Dominique, Harper, Kelly, Dubois, Claire M.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482059/
https://ncbi.nlm.nih.gov/pubmed/28635961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15884
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