An HNF4α–microRNA-194/192 signaling axis maintains hepatic cell function

Hepatocyte nuclear factor 4α (HNF4α) controls the expression of liver-specific protein-coding genes. However, some microRNAs are also modulated by HNF4α, and it is not known whether they are direct targets of HNF4α and whether they influence hepatic function. In this study, we found that HNF4α regul...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Morimoto, Aoi, Kannari, Mana, Tsuchida, Yuichi, Sasaki, Shota, Saito, Chinatsu, Matsuta, Tsuyoshi, Maeda, Tsukasa, Akiyama, Megumi, Nakamura, Takahiro, Sakaguchi, Masakiyo, Nameki, Nobukazu, Gonzalez, Frank J., Inoue, Yusuke
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481564/
https://ncbi.nlm.nih.gov/pubmed/28465351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.785592
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