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Prevention of long-term memory loss after retrieval by an endogenous CaMKII inhibitor

CaMK2N1 and CaMK2N2 are endogenous inhibitors of calcium/calmodulin-dependent protein kinase II (CaMKII), a key synaptic signaling molecule for learning and memory. Here, we investigated the learning and memory function of CaMK2N1 by knocking-down its expression in dorsal hippocampus of mice. We fou...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Vigil, Fabio Antonio, Mizuno, Keiko, Lucchesi, Walter, Valls-Comamala, Victoria, Giese, Karl Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481336/
https://ncbi.nlm.nih.gov/pubmed/28642476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04355-8
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