Liberated PKA catalytic subunits associate with the membrane via myristoylation to preferentially phosphorylate membrane substrates

Protein kinase A (PKA) has diverse functions in neurons. At rest, the subcellular localization of PKA is controlled by A-kinase anchoring proteins (AKAPs). However, the dynamics of PKA upon activation remain poorly understood. Here we report that elevation of cAMP in neuronal dendrites causes a sign...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Tillo, Shane E., Xiong, Wei-Hong, Takahashi, Maho, Miao, Sheng, Andrade, Adriana L., Fortin, Dale A., Yang, Guang, Qin, Maozhen, Smoody, Barbara F., Stork, Philip J. S., Zhong, Haining
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481286/
https://ncbi.nlm.nih.gov/pubmed/28423323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.03.070
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