Sarpogrelate hydrochloride ameliorates diabetic nephropathy associated with inhibition of macrophage activity and inflammatory reaction in db/db mice

The aim of this study was to evaluate the effects of sarpogrelate hydrochloride (SH), a selective serotonin 2A receptor antagonist, on diabetic nephropathy in a type 2 diabetes mouse model. We treated db/m and db/db mice with SH (30 mg/kg/day) for 12 weeks. Rat renal proximal tubule cells (NRK-52E)...

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Publicado en:PLoS One
Autores principales: Lee, Eun Soo, Lee, Mi Young, Kwon, Mi-Hye, Kim, Hong Min, Kang, Jeong Suk, Kim, You Mi, Lee, Eun Young, Chung, Choon Hee
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5480859/
https://ncbi.nlm.nih.gov/pubmed/28640832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179221
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