Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis

Healthy individuals of African ancestry have neutropenia that has been linked with the variant rs2814778(G) of the gene encoding atypical chemokine receptor 1 (ACKR1). This polymorphism selectively abolishes the erythroid cell expression of ACKR1, causing Duffy-negative phenotype. Here we describe a...

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Published in:Nat Immunol
Main Authors: Duchene, Johan, Novitzky-Basso, Igor, Thiriot, Aude, Casanova-Acebes, Maria, Bianchini, Mariaelvy, Etheridge, S. Leah, Hub, Elin, Nitz, Katrin, Artinger, Katharina, Eller, Kathrin, Caamaño, Jorge, Rülicke, Thomas, Moss, Paul, Megens, Remco T. A., von Andrian, Ulrich H., Hidalgo, Andres, Weber, Christian, Rot, Antal
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5480598/
https://ncbi.nlm.nih.gov/pubmed/28553950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3763
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