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Characterization of non-heme iron aliphatic halogenase WelO5* from Hapalosiphon welwitschii IC-52-3: Identification of a minimal protein sequence motif that confers enzymatic chlorination specificity in the biosynthesis of welwitindolelinones
The in vitro biochemical characterization revealed that iron/2-oxoglutarate (Fe/2OG)-dependent aliphatic halogenase WelO5* in Hapalosiphon welwitschii IC-52-3 has an enhanced substrate specificity towards 12-epi-hapalindole C (1) in comparison to WelO5 in H. welwitschii UTEX B1830. This allowed us t...
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| Published in: | Beilstein J Org Chem |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Beilstein-Institut
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5480362/ https://ncbi.nlm.nih.gov/pubmed/28684995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.13.115 |
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