Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single arm, phase 2 trial

BACKGROUND: Patients with metastatic urothelial carcinoma have limited treatment options after failure of platinum-based chemotherapy. This multicenter, single-arm phase 2 trial evaluated atezolizumab, an engineered humanized IgG1 monoclonal antibody that binds selectively to programmed death–ligand...

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Detalhes bibliográficos
Publicado no:Lancet
Main Authors: Rosenberg, Jonathan E., Hoffman-Censits, Jean, Powles, Tom, van der Heijden, Michiel S., Balar, Arjun V., Necchi, Andrea, Dawson, Nancy, O’Donnell, Peter H., Balmanoukian, Ani, Loriot, Yohann, Srinivas, Sandy, Retz, Margitta M., Grivas, Petros, Joseph, Richard W., Galsky, Matthew D., Fleming, Mark T., Petrylak, Daniel P., Perez-Gracia, Jose Luis, Burris, Howard A., Castellano, Daniel, Canil, Christina, Bellmunt, Joaquim, Bajorin, Dean, Nickles, Dorothee, Bourgon, Richard, Frampton, Garrett M., Cui, Na, Mariathasan, Sanjeev, Abidoye, Oyewale, Fine, Gregg D., Dreicer, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5480242/
https://ncbi.nlm.nih.gov/pubmed/26952546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(16)00561-4
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