Chemokine receptor CXCR4 regulates CaMKII/CREB pathway in spinal neurons that underlies cancer-induced bone pain

We previously demonstrated that the chemokine receptor CXCR4 plays an important role in cancer-induced bone pain by activating spinal neurons and glial cells. However, the specific neuronal mechanism of CXCR4 signaling is not clear. We further report that CXCR4 contributes to the activation of the n...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hu, Xue-Ming, Zhang, Hui, Xu, Heng, Zhang, Hai-Long, Chen, Li-Ping, Cui, Wen-Qiang, Yang, Wei, Shen, Wen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479786/
https://ncbi.nlm.nih.gov/pubmed/28638088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04198-3
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