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Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus

Staphylococcus aureus is known to generate small colony variants (SCVs) that are resistant to aminoglycoside antibiotics and can cause persistent and recurrent infections. The SCV phenotype is unstable, and compensatory mutations lead to restored growth, usually with loss of resistance. However, the...

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Опубликовано в: :mBio
Главные авторы: Cao, Sha, Huseby, Douglas L., Brandis, Gerrit, Hughes, Diarmaid
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478891/
https://ncbi.nlm.nih.gov/pubmed/28634236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00358-17
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