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Thalamic Ca(v)3.1 T-type Ca(2)+ channel plays a crucial role in stabilizing sleep

It has long been suspected that sensory signal transmission is inhibited in the mammalian brain during sleep. We hypothesized that Ca(v)3.1 T-type Ca(2+) channel currents inhibit thalamic sensory transmission to promote sleep. We found that T-type Ca(2+) channel activation caused prolonged inhibitio...

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Autors principals: Anderson, Matthew P., Mochizuki, Takatoshi, Xie, Jinghui, Fischler, Walter, Manger, Jules P., Talley, Edmund M., Scammell, Thomas E., Tonegawa, Susumu
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC547889/
https://ncbi.nlm.nih.gov/pubmed/15677322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409644102
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