Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid

We report the crystal structure of the glycosylated ligand-binding (S1S2) domain of the kainate receptor subunit GluR6, in complex with the agonist domoate. The structure shows the expected overall homology with AMPA and NMDA receptor subunit structures but reveals an unexpected binding mode for the...

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Bibliographic Details
Main Authors: Nanao, Max H., Green, Tim, Stern-Bach, Yael, Heinemann, Stephen F., Choe, Senyon
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC547884/
https://ncbi.nlm.nih.gov/pubmed/15677325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409573102
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