Berberine attenuates convulsing behavior and extracellular glutamate and aspartate changes in 4-aminopyridine treated rats

OBJECTIVE(S): K+ channel blocker 4-aminopyridine (4-AP) stimulates the release of glutamate from nerve terminals and induces seizures. Berberine as a potential herbal drug exerts several pharmacological actions on the central nervous system including anxiolytic, anticonvulsant, and neuroprotective p...

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Publicat a:Iran J Basic Med Sci
Autors principals: Sadeghnia, Hamid Reza, Taji, Ali Reza, Forouzanfar, Fatemeh, Hosseinzadeh, Hossein
Format: Artigo
Idioma:Inglês
Publicat: Mashhad University of Medical Sciences 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478786/
https://ncbi.nlm.nih.gov/pubmed/28656093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22038/IJBMS.2017.8756
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