NUDT15, FTO, and RUNX1 genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases

BACKGROUND/AIMS: Recent genome-wide analyses have provided strong evidence concerning adverse events caused by thiopurine drugs such as azathioprine (AZA) and 6-mercaptopurine. The strong associations identified between NUDT15 p.Arg139Cys and thiopurine-induced leukopenia and severe hair loss have b...

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Dades bibliogràfiques
Publicat a:Intest Res
Autors principals: Sato, Toshiyuki, Takagawa, Tetsuya, Kakuta, Yoichi, Nishio, Akihiro, Kawai, Mikio, Kamikozuru, Koji, Yokoyama, Yoko, Kita, Yuko, Miyazaki, Takako, Iimuro, Masaki, Hida, Nobuyuki, Hori, Kazutoshi, Ikeuchi, Hiroki, Nakamura, Shiro
Format: Artigo
Idioma:Inglês
Publicat: Korean Association for the Study of Intestinal Diseases 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478757/
https://ncbi.nlm.nih.gov/pubmed/28670229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5217/ir.2017.15.3.328
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