Mito-xenophagic killing of bacteria is coordinated by a metabolic switch in dendritic cells

Chlamydiae are bacterial pathogens that grow in vacuolar inclusions. Dendritic cells (DCs) disintegrate these compartments, thereby eliminating the microbes, through auto/xenophagy, which also promotes chlamydial antigen presentation via MHC I. Here, we show that TNF-α controls this pathway by drivi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Radomski, Nadine, Kägebein, Danny, Liebler-Tenorio, Elisabeth, Karger, Axel, Rufer, Elke, Tews, Birke Andrea, Nagel, Stefanie, Einenkel, Rebekka, Müller, Anne, Rebbig, Annica, Knittler, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478671/
https://ncbi.nlm.nih.gov/pubmed/28634388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04142-5
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