Selective cyclooxygenase inhibition by SC-560 improves hepatopulmonary syndrome in cirrhotic rats

OBJECTIVE: Hepatopulmonary syndrome (HPS) is characterized by hypoxia in patients with chronic liver disease. The mechanism of HPS includes pulmonary vasodilatation, inflammation, and angiogenesis. Prostaglandins synthesized by cyclooxygenases (COX) participate in vascular responsiveness, inflammati...

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Bibliographic Details
Published in:PLoS One
Main Authors: Chang, Ching-Chih, Lee, Wen-Shin, Hsieh, Hsian-Guey, Chuang, Chiao-Lin, Huang, Hui-Chun, Lee, Fa-Yauh, Lee, Shou-Dong
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478154/
https://ncbi.nlm.nih.gov/pubmed/28632747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179809
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