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Selective cyclooxygenase inhibition by SC-560 improves hepatopulmonary syndrome in cirrhotic rats

OBJECTIVE: Hepatopulmonary syndrome (HPS) is characterized by hypoxia in patients with chronic liver disease. The mechanism of HPS includes pulmonary vasodilatation, inflammation, and angiogenesis. Prostaglandins synthesized by cyclooxygenases (COX) participate in vascular responsiveness, inflammati...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Chang, Ching-Chih, Lee, Wen-Shin, Hsieh, Hsian-Guey, Chuang, Chiao-Lin, Huang, Hui-Chun, Lee, Fa-Yauh, Lee, Shou-Dong
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478154/
https://ncbi.nlm.nih.gov/pubmed/28632747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179809
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