Serotonin transporter binding and motor onset of Parkinson's disease in asymptomatic LRRK2 mutation carriers: a cross-sectional study

BACKGROUND: Patients with Parkinson’s Disease (PD) may exhibit premotor neurochemical changes in dopaminergic (DA) and nondopaminergic systems. Using positron emission tomography (PET), we studied participants with leucine-rich repeat kinase 2 (LRRK2) mutations and with sporadic PD to assess whether...

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Vydáno v:Lancet Neurol
Hlavní autoři: Wile, Daryl J, Agarwal, Pankaj A, Schulzer, Michael, Mak, Edwin, Dinelle, Katherine, Shahinfard, Elham, Vafai, Nasim, Hasegawa, Kazuko, Zhang, Jing, McKenzie, Jessamyn, Neilson, Nicole, Strongosky, Audrey, Uitti, Ryan J, Guttman, Mark, Zabetian, Cyrus P, Ding, Yu-Shin, Adam, Mike, Aasly, Jan, Wszolek, Zbigniew K, Farrer, Matthew, Sossi, Vesna, Stoessl, A Jon
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477770/
https://ncbi.nlm.nih.gov/pubmed/28336296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1474-4422(17)30056-X
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