Mps1 regulates kinetochore-microtubule attachment stability via the Ska complex to ensure error-free chromosome segregation

The spindle assembly checkpoint (SAC) kinase Mps1 not only inhibits anaphase but also corrects erroneous attachments that could lead to missegregation and aneuploidy. However, Mps1’s error correction-relevant substrates are unknown. Using a chemically tuned kinetochore-targeting assay, we show that...

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Veröffentlicht in:Dev Cell
Hauptverfasser: Maciejowski, John, Drechsler, Hauke, Grundner-Culemann, Kathrin, Ballister, Edward R., Rodriguez-Rodriguez, Jose-Antonio, Rodriguez-Bravo, Veronica, Jones, Mathew J.K., Foley, Emily, Lampson, Michael A., Daub, Henrik, McAinsh, Andrew D., Jallepalli, Prasad V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477644/
https://ncbi.nlm.nih.gov/pubmed/28441529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.03.025
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