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Mps1 regulates kinetochore-microtubule attachment stability via the Ska complex to ensure error-free chromosome segregation
The spindle assembly checkpoint (SAC) kinase Mps1 not only inhibits anaphase but also corrects erroneous attachments that could lead to missegregation and aneuploidy. However, Mps1’s error correction-relevant substrates are unknown. Using a chemically tuned kinetochore-targeting assay, we show that...
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| 出版年: | Dev Cell |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5477644/ https://ncbi.nlm.nih.gov/pubmed/28441529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.03.025 |
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