Silencing NKG2D ligand-targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer

NKG2D is one of the major activating receptors of natural killer (NK) cells and binds to several ligands (NKG2DLs). NKG2DLs are expressed on malignant cells and sensitize them to early elimination by cytotoxic lymphocytes. We investigated the clinical importance of NKG2DLs and the mechanism of NKG2D...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Shen, Jiaying, Pan, Jie, Du, Chengyong, Si, Wengong, Yao, Minya, Xu, Liang, Zheng, Huilin, Xu, Mingjie, Chen, Danni, Wang, Shu, Fu, Peifen, Fan, Weimin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477582/
https://ncbi.nlm.nih.gov/pubmed/28383557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.158
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