β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain

Mechanisms of acute pain transition to chronic pain are not fully understood. Here we demonstrate an active role of β-arrestin 2 (Arrb2) in regulating spinal cord NMDA receptor (NMDAR) function and the duration of pain. Intrathecal injection of the mu-opioid receptor agonist [D-Ala(2), NMe-Phe(4), G...

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Publicado no:Nat Commun
Main Authors: Chen, Gang, Xie, Rou-Gang, Gao, Yong-Jing, Xu, Zhen-Zhong, Zhao, Lin-Xia, Bang, Sangsu, Berta, Temugin, Park, Chul-Kyu, Lay, Mark, Chen, Wei, Ji, Ru-Rong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477285/
https://ncbi.nlm.nih.gov/pubmed/27538456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12531
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