GITR ligand fusion protein agonist enhances the tumor antigen–specific CD8 T-cell response and leads to long-lasting memory

BACKGROUND: The expansion of antigen-specific CD8 T cells is important in generating an effective and long-lasting immune response to tumors and viruses. Glucocorticoid-induced tumor necrosis factor receptor family-related receptor (GITR) is a co-stimulatory receptor that binds the GITR ligand (GITR...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Immunother Cancer
Auteurs principaux: Durham, Nick M., Holoweckyj, Nick, MacGill, Randall S., McGlinchey, Kelly, Leow, Ching Ching, Robbins, Scott H.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477245/
https://ncbi.nlm.nih.gov/pubmed/28649380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-017-0247-0
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