Proinflammatory Cytokines IL-6 and TNF-α Increased Telomerase Activity through NF-κB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells

There are increasing evidences of proinflammatory cytokine involvement in cancer development. Here, we found that two cytokines, IL-6 and TNF-α, activated colorectal cancer cells to be more invasive and stem-like. Combined treatment of IL-6 and TNF-α phosphorylated transcription factors STAT3 in a s...

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Detalhes bibliográficos
Publicado no:Mediators Inflamm
Main Authors: Chung, Seyung S., Wu, Yong, Okobi, Quincy, Adekoya, Debbie, Atefi, Mohammad, Clarke, Orette, Dutta, Pranabananda, Vadgama, Jaydutt V.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476880/
https://ncbi.nlm.nih.gov/pubmed/28676732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/5958429
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