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SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression

SMYD3 is a methyltransferase highly expressed in many types of cancer. It usually functions as an oncogenic protein to promote cell cycle, cell proliferation, and metastasis. Here, we show that SMYD3 modulates another hallmark of cancer, DNA repair, by stimulating transcription of genes involved in...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chen, Yun-Ju, Tsai, Cheng-Hui, Wang, Pin-Yu, Teng, Shu-Chun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476597/
https://ncbi.nlm.nih.gov/pubmed/28630472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03385-6
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