ERK1/2 signaling is required for the initiation but not progression of TGFβ-induced lens epithelial to mesenchymal transition (EMT)

Transforming Growth Factor Beta (TGFβ) potently induces lens epithelial to mesenchymal transition (EMT). The resultant mesenchymal cells resemble those found in plaques of human forms of subcapsular cataract. Smad signaling has long been implicated as the sole driving force of TGFβ-mediated activity...

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Bibliographic Details
Published in:Exp Eye Res
Main Authors: Wojciechowski, Magdalena C., Mahmutovic, Leila, Shu, Daisy. Y., Lovicu, Frank J.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476419/
https://ncbi.nlm.nih.gov/pubmed/28365272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2017.03.012
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