Mis-targeting of the mitochondrial protein LIPT2 leads to apoptotic cell death

Lipoyl(Octanoyl) Transferase 2 (LIPT2) is a protein involved in the post-translational modification of key energy metabolism enzymes in humans. Defects of lipoic acid synthesis and transfer start to emerge as causes of fatal or severe early-onset disease. We show that the first 31 amino acids of the...

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Publicat a:PLoS One
Autors principals: Bernardinelli, Emanuele, Costa, Roberta, Scantamburlo, Giada, To, Janet, Morabito, Rossana, Nofziger, Charity, Doerrier, Carolina, Krumschnabel, Gerhard, Paulmichl, Markus, Dossena, Silvia
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476274/
https://ncbi.nlm.nih.gov/pubmed/28628643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179591
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