TRTH-29. CONTEXT-SPECIFIC TUMOR SUPPRESSIVE FUNCTION OF THE CANONICAL WNT PATHWAY IN PEDIATRIC MEDULLOBLASTOMA HIGHLIGHTS A THERAPEUTIC STRATEGY FOR TREATMENT-REFRACTORY SUBGROUPS

Current molecular subgroups of childhood medulloblastoma (MB) recognize distinct disease entities of which activated Wnt signaling is associated with a distinct subgroup and the best overall outcome. In contrast, non-Wnt MBs are characterized by metastatic disease, increased rate of recurrence, and...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Manoranjan, Branavan, Venugopal, Chitra, Kameda-Smith, Michelle, Bakhshinyan, David, Subapanditha, Minomi, Doble, Bradley, Singh, Sheila
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Abstracts
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475246/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.239
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