TMOD-06. PRIMARY CELL LINES OF PEDIATRIC HIGH GRADE GLIOMAS (PHGGS) WITH HISTONE H3.3 MUTATIONS ARE MIMICKING INTER AND INTRA-TUMOR HETEROGENEITY

Children diagnosed for pHGGs, comprising mostly tumors of the brain midline (brainstem and thalamic locations), are facing with a very dismal prognosis. Those brain cancers are bearing usually and in more than 80% of the cases the histone H3.3 mutations. Up to now, the only therapy improving transie...

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Publicado en:Neuro Oncol
Main Authors: Blandin, Anne-Florence, Durand, Aurélie, Litzler, Marie, Guerin, Eric, Tripp, Aurelien, Lelong-Rebel, Isabelle, Dontenwill, Monique, Namer, Izzie Jacques, Guenot, Dominique, Entz-Werle, Natacha
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475244/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.205
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