Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases

Antigen-activated lymphocytes undergo extraordinarily rapid cell division in the course of immune responses. We hypothesized that this unique aspect of lymphocyte biology leads to unusual genomic stress in recently antigen-activated lymphocytes and that targeted manipulation of DNA damage-response (...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: McNally, Jonathan P., Millen, Scott H., Chaturvedi, Vandana, Lakes, Nora, Terrell, Catherine E., Elfers, Eileen E., Carroll, Kaitlin R., Hogan, Simon P., Andreassen, Paul R., Kanter, Julie, Allen, Carl E., Henry, Michael M., Greenberg, Jay N., Ladisch, Stephan, Hermiston, Michelle L., Joyce, Michael, Hildeman, David A., Katz, Jonathan D., Jordan, Michael B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474825/
https://ncbi.nlm.nih.gov/pubmed/28533414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703683114
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