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A mechanism for lipid binding to apoE and the role of intrinsically disordered regions coupled to domain–domain interactions
Relative to the apolipoprotein E (apoE) E3 allele of the APOE gene, apoE4 strongly increases the risk for the development of late-onset Alzheimer’s disease. However, apoE4 differs from apoE3 by only a single amino acid at position 112, which is arginine in apoE4 and cysteine in apoE3. It remains unc...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5474821/ https://ncbi.nlm.nih.gov/pubmed/28559318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705080114 |
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