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An ubiquitin-dependent balance between mitofusin turnover and fatty acids desaturation regulates mitochondrial fusion

Mitochondrial integrity relies on homotypic fusion between adjacent outer membranes, which is mediated by large GTPases called mitofusins. The regulation of this process remains nonetheless elusive. Here, we report a crosstalk between the ubiquitin protease Ubp2 and the ubiquitin ligases Mdm30 and R...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Cavellini, Laetitia, Meurisse, Julie, Findinier, Justin, Erpapazoglou, Zoi, Belgareh-Touzé, Naïma, Weissman, Allan M., Cohen, Mickael M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474747/
https://ncbi.nlm.nih.gov/pubmed/28607491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15832
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