Neutrophil Protease Cleavage of Von Willebrand Factor in Glomeruli – An Anti-thrombotic Mechanism in the Kidney

Adequate cleavage of von Willebrand factor (VWF) prevents formation of thrombi. ADAMTS13 is the main VWF-cleaving protease and its deficiency results in development of thrombotic microangiopathy. Besides ADAMTS13 other proteases may also possess VWF-cleaving activity, but their physiological importa...

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Dettagli Bibliografici
Pubblicato in:EBioMedicine
Autori principali: Tati, Ramesh, Kristoffersson, Ann-Charlotte, Manea Hedström, Minola, Mörgelin, Matthias, Wieslander, Jörgen, van Kooten, Cees, Karpman, Diana
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
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Review Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474509/
https://ncbi.nlm.nih.gov/pubmed/28139439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.01.032
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