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DNA sequence homology induces cytosine-to-thymine mutation by a heterochromatin-related pathway in Neurospora

Eukaryotic genomes contain substantial amounts of repetitive DNA organized in the form of constitutive heterochromatin and associated with repressive epigenetic modifications, such as H3K9me3 and C5-cytosine methylation (5mC). In the fungus Neurospora crassa, H3K9me3 and 5mC are catalyzed, respectiv...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Gladyshev, Eugene, Kleckner, Nancy
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474309/
https://ncbi.nlm.nih.gov/pubmed/28459455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3857
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