تحميل...
Nucleotide based covalent inhibitors of KRas can only be efficient in vivo if they bind reversibly with GTP-like affinity
Simple reversible competitive inhibition of nucleotide binding of GTP to Ras family GTPases has long been recognized as an unlikely approach to manipulating the activity of such proteins for experimental or therapeutic purposes. This is due to the high affinity of GTP to GTPases coupled with high ce...
محفوظ في:
| الحاوية / القاعدة: | Sci Rep |
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| المؤلفون الرئيسيون: | , , , , |
| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
Nature Publishing Group UK
2017
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5473928/ https://ncbi.nlm.nih.gov/pubmed/28623374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03973-6 |
| الوسوم: |
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