High-Risk Human Papillomavirus E7 Alters Host DNA Methylome and Represses HLA-E Expression in Human Keratinocytes

Human papillomavirus (HPV) infection distinctly alters methylation patterns in HPV-associated cancer. We have recently reported that HPV E7-dependent promoter hypermethylation leads to downregulation of the chemokine CXCL14 and suppression of antitumor immune responses. To investigate the extent of...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Cicchini, Louis, Blumhagen, Rachel Z., Westrich, Joseph A., Myers, Mallory E., Warren, Cody J., Siska, Charlotte, Raben, David, Kechris, Katerina J., Pyeon, Dohun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473897/
https://ncbi.nlm.nih.gov/pubmed/28623356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03295-7
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