Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb) expresses a broad-spectrum β-lactamase (BlaC) that mediates resistance to one of the highly effective antibacterials, β-lactams. Nonetheless, β-lactams showed mycobactericidal activity in combination with β-lactamase inhibitor, clavulanate (Clav). However, the mechan...

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Publicado en:eLife
Autores principales: Mishra, Saurabh, Shukla, Prashant, Bhaskar, Ashima, Anand, Kushi, Baloni, Priyanka, Jha, Rajiv Kumar, Mohan, Abhilash, Rajmani, Raju S, Nagaraja, Valakunja, Chandra, Nagasuma, Singh, Amit
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473688/
https://ncbi.nlm.nih.gov/pubmed/28548640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25624
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