Disruption of the Axonal Trafficking of Tyrosine Hydroxylase mRNA Impairs Catecholamine Biosynthesis in the Axons of Sympathetic Neurons

Tyrosine hydroxylase (TH) is the enzyme that catalyzes the rate-limiting step in the biosynthesis of the catecholamine neurotransmitters. In a previous communication, evidence was provided that TH mRNA is trafficked to the axon, where it is locally translated. In addition, a 50-bp sequence element i...

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Veröffentlicht in:eNeuro
Hauptverfasser: Aschrafi, Armaz, Gioio, Anthony E., Dong, Lijin, Kaplan, Barry B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2017
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New Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473686/
https://ncbi.nlm.nih.gov/pubmed/28630892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0385-16.2017
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