Pioglitazone Treatment Following Spinal Cord Injury Maintains Acute Mitochondrial Integrity and Increases Chronic Tissue Sparing and Functional Recovery

Pioglitazone is an FDA-approved PPAR-γ agonist drug used to for treat diabetes, and it has demonstrated neuroprotective effects in multiple models of central nervous system (CNS) injury. Acute treatment after spinal cord injury (SCI) in rats is reported to suppress neuroinflammation, rescue injured...

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Gepubliceerd in:Exp Neurol
Hoofdauteurs: Patel, Samir P., Cox, David H., Gollihue, Jenna L., Bailey, William M., Geldenhuys, Werner J., Gensel, John C., Sullivan, Patrick G., Rabchevsky, Alexander G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473659/
https://ncbi.nlm.nih.gov/pubmed/28365473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2017.03.021
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