Principles of early human development and germ cell program from conserved model systems

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during week 2-3 of early postimplantation development1. Using in vitro models of hPGC induction2–4, recent studies suggest striking mechanistic differences in specification of human and mouse PGCs5. This may partly be d...

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Bibliographic Details
Published in:Nature
Main Authors: Kobayashi, Toshihiro, Zhang, Haixin, Tang, Walfred W.C., Irie, Naoko, Withey, Sarah, Klisch, Doris, Sybirna, Anastasiya, Dietmann, Sabine, Contreras, David A., Webb, Robert, Allegrucci, Cinzia, Alberio, Ramiro, Surani, M. Azim
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473469/
https://ncbi.nlm.nih.gov/pubmed/28607482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22812
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