Novel Plasmodium vivax dhfr Alleles from the Indonesian Archipelago and Papua New Guinea: Association with Pyrimethamine Resistance Determined by a Saccharomyces cerevisiae Expression System

In plasmodia, the dihydrofolate reductase (DHFR) enzyme is the target of the pyrimethamine component of sulfadoxine-pyrimethamine (S/P). Plasmodium vivax infections are not treated intentionally with antifolates. However, outside Africa, coinfections with Plasmodium falciparum and P. vivax are commo...

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Autori principali: Hastings, Michele D., Maguire, Jason D., Bangs, Michael J., Zimmerman, Peter A., Reeder, John C., Baird, J. Kevin, Sibley, Carol Hopkins
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC547327/
https://ncbi.nlm.nih.gov/pubmed/15673758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.2.733-740.2005
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