Activation of PERK Elicits Memory Impairment through Inactivation of CREB and Downregulation of PSD95 After Traumatic Brain Injury

The PKR-like ER kinase (PERK), a transmembrane protein, resides in the endoplasmic reticulum (ER). Its activation serves as a key sensor of ER stress, which has been implicated in traumatic brain injury (TBI). The loss of memory is one of the most common symptoms after TBI, but the precise role of P...

Full description

Saved in:
Bibliographic Details
Published in:J Neurosci
Main Authors: Sen, Tanusree, Gupta, Rajaneesh, Kaiser, Helen, Sen, Nilkantha
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2017
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473207/
https://ncbi.nlm.nih.gov/pubmed/28522733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2343-16.2017
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items