Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors

BACKGROUND: A high rate of glycolysis leading to elevated lactate content has been linked to poor clinical outcomes in patients with head and neck and cervical cancer treated with radiotherapy. Although the biological explanation for this relationship between lactate and treatment response remains u...

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Publicado en:BMC Cancer
Main Authors: Leung, Eric, Cairns, Rob A., Chaudary, Naz, Vellanki, Ravi N., Kalliomaki, Tuula, Moriyama, Eduardo H., Mujcic, Hilda, Wilson, Brian C., Wouters, Bradly G., Hill, Richard, Milosevic, Michael
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2017
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473006/
https://ncbi.nlm.nih.gov/pubmed/28619042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3402-6
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