Transgenic Overexpression of CD39 Protects Against Renal Ischemia-Reperfusion and Transplant Vascular Injury

The vascular ectonucleotidases CD39 [ENTPD1 (ec-tonucleoside triphosphate diphosphohydrolase-1), EC 3.6.1.5] and CD73 [EC 3.1.3.5] generate adenosine from extracellular nucleotides. CD39 activity is critical in determining the response to ischemia-reperfusion injury (IRI), and CD39 null mice exhibit...

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Publicat a:Am J Transplant
Autors principals: Crikis, S., Lu, B., Murray-Segal, L. M., Selan, C., Robson, S. C., d’Apice, A. J. F., Nandurkar, H. H., Cowan, P. J., Dwyer, K. M.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472986/
https://ncbi.nlm.nih.gov/pubmed/20840479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2010.03257.x
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