TGF-beta/atRA-induced Tregs express a selected set of microRNAs involved in the repression of transcripts related to Th17 differentiation

Regulatory T cells (Tregs) are essential regulators of immune tolerance. atRA and TGF-β can inhibit the polarization of naïve T cells into inflammatory Th17 cells, favoring the generation of stable iTregs, however the regulatory mechanisms involved are not fully understood. In this context, the role...

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Udgivet i:Sci Rep
Main Authors: Schiavinato, Josiane Lilian dos Santos, Haddad, Rodrigo, Saldanha-Araujo, Felipe, Baiochi, João, Araujo, Amélia Goes, Santos Scheucher, Priscila, Covas, Dimas Tadeu, Zago, Marco Antonio, Panepucci, Rodrigo Alexandre
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472579/
https://ncbi.nlm.nih.gov/pubmed/28620241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03456-8
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