Dengue virus activates cGAS through the release of mitochondrial DNA

Cyclic GMP-AMP synthetase (cGAS) is a DNA-specific cytosolic sensor, which detects and initiates host defense responses against microbial DNA. It is thus curious that a recent study identified cGAS as playing important roles in inhibiting positive-sense single-stranded RNA (+ssRNA) viral infection,...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Sun, Bo, Sundström, Karin B., Chew, Jun Jie, Bist, Pradeep, Gan, Esther S., Tan, Hwee Cheng, Goh, Kenneth C., Chawla, Tanu, Tang, Choon Kit, Ooi, Eng Eong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472572/
https://ncbi.nlm.nih.gov/pubmed/28620207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03932-1
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